2nd International Tumor Metabolism Summit

[pro]

On behalf of my co-organizers, Giovanni Melillo and Luigi Varesio, I am writing to invite you to attend the 2nd International Tumor Metabolism Summit in Genoa, Italy on October 7 -8, 2005.

TMS 2005 will feature some of the world's leading cancer research scientists including:

Giovanni Melillo, MD

Senior Investigator - National Cancer Institute at Frederick

Paolo M. Comoglio, MD, PhD

Full Professor of Histology, University of Turin School of Medicine and Scientific Director, Institute for Cancer Research and Treatment

Chi V. Dang, MD, PhD

Professor in Oncology Research; Vice Dean for Research - Johns Hopkins University School of Medicine

Amato J. Giaccia, PhD

Professor, Radiation Oncology; Director, Division of Cancer and Radiation Biology - Stanford University School of Medicine

Adrian L. Harris, MD, PhD

Professor - Cancer Research UK, Oxford Cancer Centre

Randall S. Johnson, PhD

Guest Professor - Karolinska Institute

Eric J. Stanbridge, PhD

Distinguished Professor - University of California Irvine

Luigi Varesio, PhD

Chief, Laboratory of Molecular Biology - Giannina Gaslini Institute, Genoa

This year's conference will focus on exciting new advances in the understanding of molecular, cellular and tissue responses to the tumor microenvironment.

Invited speakers will present their most recent findings in this field, which is increasingly being appreciated as a critical aspect of tumor biology. These presentations will include:

New insights into the molecular mechanisms controlling tumor cell metabolism

New advances in understanding the role of HIF-1 in responses to hypoxia

Selective markers for hypoxia and novel therapeutic approaches to treat cancer based on the tumor microenvironment.

Space will be limited to a small number of attendees - making this a unique chance to meet and interact personally with these leading experts.

In addition, we are inviting submission of research abstracts, which will be reviewed for platform and poster presentations at the event.

Please make sure to reserve your space soon. The deadline for registration and abstract submission is August 1.

Go to www.tmsabstracts.com for more information.

I hope you will join us for this very special event.

Sincerely,

Gregg L. Semenza, MD, PhD

Director, Vascular Biology Program

Institute for Cell Engineering

Professor of Pediatrics, Medicine, Oncology, Radiation Oncology,

And McKusick-Nathans Institute of Genetic Medicine

The Johns Hopkins University School of Medicine

[pro]

Dear Colleague:

I recently contacted you about a very special event at which I will be speaking - the 2nd International Tumor Metabolism Summit in Genoa, Italy on October 7 -8, 2005.

This year's conference will focus on ground breaking new advances in the understanding of molecular, cellular and tissue responses to the tumor microenvironment.

TMS 2005 will feature some of the world's leading cancer research scientists. Here is an update on some of the speakers and important presentation topics:

Giovanni Melillo, MD

Senior Investigator - National Cancer Institute at Frederick

"Targeting the Tumor Microenvironment: Small Molecule Inhibitors of Hypoxia Inducible Factor 1 (HIF-1)"

Paolo M. Comoglio, MD, PhD

Full Professor of Histology, University of Turin School of Medicine and Scientific Director, Institute for Cancer Research and Treatment

"Invasive Growth: A Genetic Program Linking Cancer to Hemostasis"

Chi V. Dang, MD, PhD

Professor in Oncology Research; Vice Dean for Research - Johns Hopkins University School of Medicine

"Novel Insights on Molecular Mechanisms Underlying the Warburg Effect: Myc, Akt and HIF-1"

Amato J. Giaccia, PhD

Professor, Radiation Oncology; Director, Division of Cancer and Radiation Biology - Stanford University School of Medicine

"Tumor Targeted Therapy Exploiting the HIF/VHL Pathway"

Adrian L. Harris, MD, PhD

Professor - Cancer Research UK, Oxford Cancer Centre

"Role of Carbonic Anhydrase 9 in Cancer Cell Hypoxia Response"

Randall S. Johnson, PhD

Guest Professor - Karolinska Institute

"Hypoxia and Vascularization: Angiogenesis Requires a HIF-1 Response"

Eric J. Stanbridge, PhD

Distinguished Professor - University of California Irvine

"The Tumor and Hypoxia Biomarker Carbonic Anhydrase IX: Diagnostic, Prognostic and Therapeutic Applications"

Luigi Varesio, PhD

Chief, Laboratory of Molecular Biology - Giannina Gaslini Institute, Genoa

"Response of Macrophages to Hypoxia and Picolinic Acid"

Space will be limited to a small number of attendees - making this a unique chance to meet and interact personally with these leading experts.

In addition, we are inviting submission of research abstracts, which will be reviewed for platform and poster presentations at the event.

Please make sure to reserve your space soon. The deadline for early registration and abstract submission has been extended to August 20.

Please go to www.tmsabstracts.com to register or for more information.

I hope you will join us for this very special event.

Sincerely,

Gregg L. Semenza, MD, PhD

Director, Vascular Biology Program

Institute for Cell Engineering

Professor of Pediatrics, Medicine, Oncology, Radiation Oncology,

And McKusick-Nathans Institute of Genetic Medicine

The Johns Hopkins University School of Medicine