sandy Δημοσιεύτηκε 22 Μαρτίου 2006 Aναφορά Share Δημοσιεύτηκε 22 Μαρτίου 2006 Previously applied test statistics for affected sib pairs (ASP) have been criticized for not fully exploiting the power of a given sample, because they do not account for incomplete informativity of an affected sib pair. To circumvent this problem, recently a new test had been proposed which weighs families proportional to their marker informativity. Here, the behavior of this new test is explored under scenarios considered to be relevant in the context of complex diseases. The results show that the new test does not represent an improvement. The asymptotic version of the new test tends to be markedly anti-conservative even for larger sample sizes, whereas the permutation procedure proposed for the simulation of exact P values is at least questionable. Most importantly, the new test is less powerful than its competitors, especially in case of low marker informativity it was designed for. Link to comment Μοιράσου σε άλλους δικτυακούς τόπους More sharing options...
Sovereign Δημοσιεύτηκε 22 Μαρτίου 2006 Aναφορά Share Δημοσιεύτηκε 22 Μαρτίου 2006 ο- ράιτυ δεν Link to comment Μοιράσου σε άλλους δικτυακούς τόπους More sharing options...
xalia Δημοσιεύτηκε 22 Μαρτίου 2006 Aναφορά Share Δημοσιεύτηκε 22 Μαρτίου 2006 προφανώς...... Link to comment Μοιράσου σε άλλους δικτυακούς τόπους More sharing options...
mixmavros Δημοσιεύτηκε 23 Μαρτίου 2006 Aναφορά Share Δημοσιεύτηκε 23 Μαρτίου 2006 Αναρωτιέμαι αν το έχει κάνει κανείς report.... Εγώ πάντως δεν το κανα!! Link to comment Μοιράσου σε άλλους δικτυακούς τόπους More sharing options...
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